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POS-ER-cUTI: Perpetual Observational Study among patients with complicated Urinary Tract Infections (cUTI)

Complicated Urinary Tract Infections (cUTI) are a leading cause of hospital admission and antibiotic use. These infections are more and more often caused by antibiotic-resistant bacteria, especially among patients with functional or structural abnormalities and/or of advanced age. Due to emerging antimicrobial resistance (AMR), there is a loss of effective oral antibiotics resulting in prolonged hospital admissions for intravenous treatment, increased healthcare costs, and a reduced quality of life associated with cUTI. Preventive strategies such as vaccines, and the development of rapid diagnostics, could greatly reduce the health and economic impact of cUTIs. 

The primary objective of this study is to provide an infrastructure capable of rapidly implementing randomized controlled trials (RCTs) and other clinical studies related to the treatment of cUTI.  The secondary objectives include descriptive analyses related to patient characteristics, complications, outcome and risk factors.