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POS-ICU-VAP: Perpetual Observational Study among patients at risk for developing Ventilator-Associated Pneumonia (VAP)

Ventilator-Associated Pneumonia (VAP) is a frequent complication in mechanically-ventilated ICU patients and is often caused by multi-drug resistant bacteria. Distinguishing bacterial colonization of the respiratory tract from infection of the lung tissue is extremely difficult with currently available diagnostic approaches resulting in an unnecessary use of broad-spectrum antibiotics in many patients, thereby enhancing antimicrobial resistance (AMR).

The primary objective of this study is to provide an infrastructure capable of rapidly implementing randomized controlled trials (RCTs) and other clinical trials related to prevention, diagnosis or treatment of VAP in ICUs. The secondary objectives include descriptive analyses related to patient characteristics, complications, outcome and risk factors.